Karambwan poison is a type of poison that is created from poison karambwan paste. It can only be applied to spears. The poison is discovered during Tai Bwo Wannai Trio, during which a spear must be poisoned and given to Tamayu so that he is able to defeat The Shaikahan. Karambwan poisoned spears are untradeable and can not be equipped, but a cleaning cloth can be used to remove the poison and recover the original item.
Poison karambwan paste has an "apply" option, but it does not have any effect. This means karambwan poison is not possible to use in combat.
Prior to the Evolution of Combat, karambwan poisoned spears and hastae could be equipped and used in combat. The poison could not be cured by a standard antipoison potion. It would hit a total of 1170 damage before wearing off. Because the quest requires use of a spear, poisoned spears can still be poisoned. Poisoned hastae, however can no longer be created.