Rune may refer to:
- Rune equipment, metal equipment made from runite, suitable for melee fighters
- Runite metal
- Rune Mechanics, a quest
- Rune minotaur, a summoning familiar
- Rune Mysteries, a quest
- Rune guardian, a pet
- Runes, magic stones used for casting spells via the Magic skill.
- Rune essence, the raw material that runes are made of, which players can turn into low-level runes via the Runecrafting skill.
- Pure essence, the members-only raw material that runes are made of, which members can turn into runes (usually high-level and combination runes) via the Runecrafting skill.