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For the potion flask version, see Antipoison++ flask.
Antipoison++ (1) detail.png
Antipoison++ (2) detail.png
Antipoison++ (3) detail.png
Antipoison++ (4) detail.png

Antipoison++ are made by mixing clean irit and magic roots in a vial of coconut milk, requiring 79 Herblore and giving 177.5 Herblore experience.

Antipoison++ cures poison and provides 12 minutes of immunity to poison which is the longest duration possible (aside from Ogre flask (thermal) which can last up to 14 minutes). This makes them far more useful than other types of antipoison potions, eliminating the need to drink constantly.

If your antipoison is about to run out you'll get the message: "Your immunity to poison is about to expire."

This potion can be made into an antipoison++ flask by using at least six doses of it with a potion flask. Players do not need a specific level to turn potions into flasks.

Price per dose[edit | edit source]

Item GE price Price per dose Price per dose
(Excluding vial / flask)
Antipoison++ (1).png Antipoison++ (1) 1,238 1,238 1,236
Antipoison++ (2).png Antipoison++ (2) 1,905 953 952
Antipoison++ (3).png Antipoison++ (3) 3,194 1,065 1,064
Antipoison++ (4).png Antipoison++ (4) 1,716 429 429
Antipoison++ flask (6).png Antipoison++ flask (6) 26,263 4,377 1,447

Creation[edit | edit source]

Antipoison++ (4).png Antipoison++ (4)
Herblore-Hourglass.pngMake-X GE icon.png
177.5 XP-2 (1.2s) / 1 (0.6s) [r 1]1,716
Herblore Herblore level79
P2P icon.png Members only
Antipoison++ (unf).pngAntipoison++ (unf)112,362[r 2]12,362
Magic roots.pngMagic roots16,2706,270
Total price18,632
  1. ^ When mixing a single potion
  2. ^ Calculated value given on the item page (generally based on GE prices of ingredients): [show/hide formula] Price(Coconut milk) + Price(Clean irit).

Production costs[edit | edit source]

HerbSecondaryVialMaterial costProfitProfit/XP
Clean irit.png Clean iritMagic roots.png Magic rootsCoconut milk.png Coconut milk18,632−16,916−94.77
Grimy irit.png Grimy iritMagic roots.png Magic rootsCoconut milk.png Coconut milk18,345−16,629−88.78
N/AMagic roots.png Magic rootsIrit potion (unf).png Irit potion (unf)8,167−6,451−36.34

Drop sources[edit | edit source]

Antipoison++ (4)[edit | edit source]

For an exhaustive list of all known sources for this item, see here (include RDT).

Antipoison protection comparison[edit | edit source]

Antipoison Price/dose Seconds/dose Price/second
Antipoison.png: RS3 Inventory image of AntipoisonAntipoison (4) 176.25 86 2.05
Antipoison flask.png: RS3 Inventory image of Antipoison flaskAntipoison flask (6) 3,894 86 45.28
Super antipoison.png: RS3 Inventory image of Super antipoisonSuper antipoison (4) 1,737.5 346 3.9
Super antipoison flask.png: RS3 Inventory image of Super antipoison flaskSuper antipoison flask (6) 4,989.5 346 11.19
Antipoison+.png: RS3 Inventory image of Antipoison+Antipoison+ (4) 1,781.5 518 3.44
Antipoison+ flask.png: RS3 Inventory image of Antipoison+ flaskAntipoison+ flask (6) 7,343.33 518 14.18
Antipoison++.png: RS3 Inventory image of Antipoison++Antipoison++ (4) 429 720 0.6
Antipoison++ flask.png: RS3 Inventory image of Antipoison++ flaskAntipoison++ flask (6) 4,377.17 720 6.08
Sanfew serum.png: RS3 Inventory image of Sanfew serumSanfew serum (4) 1,596.75 86 18.57
Sanfew serum flask.png: RS3 Inventory image of Sanfew serum flaskSanfew serum flask (6) 3,344.5 86 38.89
Irit incense sticks.png: RS3 Inventory image of Irit incense sticksIrit incense sticks 19,862 600 33.1

Disassembly[edit | edit source]

Update history[edit | edit source]

This information has been compiled as part of the update history project. Some updates may not be included - see here for how to help out!
  • patch 12 December 2016 (Update):
    • Can no longer apply a weaker anti-poison effect if a stronger effect is already active.
  • patch 7 February 2012 (Update):
    • There is now a warning about when anti-poison is about to wear off.