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For the potion flask version, see Antipoison++ flask.
Antipoison++ detail.png

Antipoison++ are made by mixing clean irit and magic roots in a vial of coconut milk, requiring 79 Herblore and giving 177.5 Herblore experience.

Antipoison++ cures poison and provides 12 minutes of immunity to poison which is the longest duration possible (aside from Ogre flask (thermal) which can last up to 14 minutes). This makes them far more useful than other types of antipoison potions, eliminating the need to drink constantly.

If your antipoison is about to run out you'll get the message: "Your immunity to poison is about to expire."

This potion can be made into an antipoison++ flask by using at least six doses of it with a potion flask. Players do not need a specific level to turn potions into flasks.

Price per dose[edit | edit source]

Item GE price Price per dose Price per dose
(Excluding vial / flask)
Antipoison++ (1).png Antipoison++ (1) 1,101 1,101 1,100
Antipoison++ (2).png Antipoison++ (2) 2,077 1,039 1,038
Antipoison++ (3).png Antipoison++ (3) 3,757 1,252 1,252
Antipoison++ (4).png Antipoison++ (4) 3,563 891 891
Antipoison++ flask (6).png Antipoison++ flask (6) 26,704 4,451 1,994

Creation[edit | edit source]

Antipoison++ (4).png Antipoison++ (4)
Herblore-Hourglass.pngMake-X GE icon.png
177.5 XP-2 (1.2s) / 1 (0.6s) [recipe 1]3,563
Herblore Herblore level79
P2P icon.png Members only
Antipoison++ (unf).pngAntipoison++ (unf)1N/A-
Magic roots.pngMagic roots13,5033,503
  1. ^ When mixing a single potion

Production costs[edit | edit source]

HerbSecondaryVialMaterial costProfitProfit/XP
Clean irit.png Clean iritMagic roots.png Magic rootsCoconut milk.png Coconut milk17,002-13,245-74.2
Grimy irit.png Grimy iritMagic roots.png Magic rootsCoconut milk.png Coconut milk16,645-12,888-68.81
N/AMagic roots.png Magic rootsIrit potion (unf).png Irit potion (unf)8,018-4,261-24.01

Drop sources[edit | edit source]

Antipoison++ (4)[edit | edit source]

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For an exhaustive list of all known sources for this item, see here (include RDT).

Antipoison protection comparison[edit | edit source]

Antipoison Price/dose Seconds/dose Price/second
Antipoison.png: RS3 Inventory image of AntipoisonAntipoison (4) 172.5 86 2.01
Antipoison flask.png: RS3 Inventory image of Antipoison flaskAntipoison flask (6) 2,331.5 86 27.11
Super antipoison.png: RS3 Inventory image of Super antipoisonSuper antipoison (4) 2,847.75 346 6.39
Super antipoison flask.png: RS3 Inventory image of Super antipoison flaskSuper antipoison flask (6) 5,301.67 346 11.89
Antipoison+.png: RS3 Inventory image of Antipoison+Antipoison+ (4) 1,612.5 518 3.11
Antipoison+ flask.png: RS3 Inventory image of Antipoison+ flaskAntipoison+ flask (6) 6,029 518 11.64
Antipoison++.png: RS3 Inventory image of Antipoison++Antipoison++ (4) 890.75 720 1.24
Antipoison++ flask.png: RS3 Inventory image of Antipoison++ flaskAntipoison++ flask (6) 4,450.67 720 6.18
Sanfew serum.png: RS3 Inventory image of Sanfew serumSanfew serum (4) 1,561.5 86 18.16
Sanfew serum flask.png: RS3 Inventory image of Sanfew serum flaskSanfew serum flask (6) 3,239 86 37.66
Irit incense sticks.png: RS3 Inventory image of Irit incense sticksIrit incense sticks 26,245 600 43.74

Disassembly[edit | edit source]

Update history[edit | edit source]

The update history project is a work-in-progress – not all updates to this topic may be covered below. See here for how to help out!
  • patch 12 December 2016 (Update):
    • Can no longer apply a weaker anti-poison effect if a stronger effect is already active.
  • patch 7 February 2012 (Update):
    • There is now a warning about when anti-poison is about to wear off.